Note to visitors: This section use to house all the protocols and minor insights I uncovered while doing lab experiments. Unfortunately, my old WordPress website was poorly secured and also not backed up well, was hacked, and all of myt word was lost. I will put up all the content back as soon as it is recovered. I have recently migrated to Hugo and I am already loving it.
Research interests
I love studying the microscopic and macroscopic realms that construct our reality. My research interests span infectious diseases, aging, molecular imaging, and structural biology. I have previously worked on various research projects, including anti-dengue drug discovery, antimicrobial drug discovery against ESKAPE pathogens, and natural product chemistry.
Selected publications
Please open the collapsible section below to view the list of publications.
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Shilkar D, Mohd Siddique MU, Bua S et al. Carbonic anhydrase inhibitory activity of phthalimide-capped benzene sulphonamide derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry. 2023;38(1):2235089.
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Shyam M, Shilkar D, Rakshit G, Jayaprakash V. Approaches for targeting the mycobactin biosynthesis pathway for novel anti-tubercular drug discovery: Where we stand. Expert Opinion on Drug Discovery. 2022;17(7):699.
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Murtuja S, Shilkar D, Sarkar B, Sinha BN, Jayaprakash V. A critical observation on the design and development of reported peptide inhibitors of DENV NS2B-NS3 protease in the last two decades. Mini Reviews in Medicinal Chemistry. 2022;22(8):1108. doi:10.2174/1389557521666211101154619.
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Kumar Deb P, Shilkar D, Sarkar B. UHPLC-ESI-QTOF-MS/MS based identification, quantification, and assessment of in silico molecular interactions of major phytochemicals from bioactive fractions of Clerodendrum glandulosum Lindl. Leaves. Chemistry and Biodiversity. Oct 2022;19(10):e202200617. doi:10.1002/cbdv.202200617.
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Badavath VN, Thakur A, Shilkar D, et al. Brain permeable curcumin-based pyrazoline analogs: MAO inhibitory and antioxidant activity. Journal of Molecular Structure. 2022;1268:133681.
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Mohd Siddique MUM, Thakur A, Shilkar D, et al. Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives. European Journal of Medicinal Chemistry. 2021;223:113630.
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Shyam M, Shilkar D, Verma H, et al. The mycobactin biosynthesis pathway: A prospective therapeutic target in the battle against tuberculosis. Journal of Medicinal Chemistry. Jan 14 2021;64(1):71. doi:10.1021/acs.jmedchem.0c01176.
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Murtuja S, Shilkar D, Sarkar B, Sinha BN, Jayaprakash V. A short survey of dengue protease inhibitor development in the past 6 years (2015-2020) with an emphasis on similarities between DENV and SARS-CoV-2 proteases. Bioorganic and Medicinal Chemistry. 2021;49:116415.
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Murtuja S, Shilkar D, Sarkar B, Sinha BN, Jayaprakash V. Identification of Dengue NS2B-NS3 Protease Inhibitors Through High-Throughput Virtual Screening—Impacts on Drug Development Against the Dengue Virus. Human Viruses: Diseases, Treatments and Vaccines: The New Insights. Springer International Publishing Cham; 2021:93-120.